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Molecular BioSystems
11 Jun 2013
11 Jun 2013
Publication: This journal is©The Royal Society of Chemistry 2014
Author(s): Sneha Menon
A major challenge remaining in drug design efforts towards protein kinase is due to the development of drug resistance initiated by the missense mutations in the kinase catalytic domain. Gain or loss of function mutations in the Rearranged during Transfection (RET) tyrosine kinase gene have been associated with the development of a wide range of human....