Publication: DARU Vol. 18, No. 1 2010

Author(s): Namrata Chadha

Lamotrigine (LMG), an antiepileptic drug of Phenyltriazine class, is used for the treatment of partial seizures and those associated with the Lennox-Gastant syndrome. It is a basic drug (pKa 5.3) with an intrinsic solubility of 0.17 mg/ml and undergoes extensive hepatic metabolism upon oral administration (1)....